When statins are used in low-risk patients without heart disease primary prevention there is no mortality benefit. That’s right. Your chances of dying are the same on or off the drug, regardless of how much the statin lowers the cholesterol level.When statins are used for primary prevention, there is a small lowering of future vascular events stroke/heart attack over five to 10 years. The absolute risk reduction is in the range of seven per 1000. That means you have to treat 140 patients with a statin for five years to prevent one event. Or this: for 99.3% of statin-treated patients, there is no benefit. I like to call this the PSR, or percent same result.